CE30 - Physique de la matière condensée et de la matière diluée

Cellular droplets in and out of equilibrium – DropInOut

Submission summary

Membraneless organelles are dynamical cellular structures formed through liquid-liquid phase separation (LLPS) of proteins and nucleic acids. These ‘droplets’ are currently recognized to play a major role in organizing the cellular environment and LLPS has become a paradigm in cellular biology. Despite the ever-growing attention, we are still far from deciphering the details of these complex biomolecular assemblies, which are regulated by active processes and thus escape the boundaries of thermodynamic equilibrium. Here we will take inspiration from soft matter physics and combine a wide array of X-ray/neutron scattering experiments with advanced molecular modeling for unveiling the structural and dynamical properties of protein/RNA condensates and their assembly in equilibrium and non-equilibrium conditions. Our strategy will provide an unprecedented molecular picture of these elusive entities and elucidate the interplay between phase behavior and energy-consuming processes.

Project coordination

Alessandro BARDUCCI (Centre de biochimie structurale)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CBS Centre de biochimie structurale
CBS Centre de biochimie structurale
LPS Laboratoire de Physique des Solides

Help of the ANR 494,038 euros
Beginning and duration of the scientific project: December 2021 - 48 Months

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