CE20 - Biologie des animaux, des organismes photosynthétiques et des microorganismes

A 4D Nucleome approach to identify enhancers controlling tomato heat stress response – 4D-Heat

Submission summary

Tomato is one of the most important vegetable crops for production and world trade. In the future the tomato demand is expected to increase by 60% by 2050, but climate change is an obstacle for yield increase. In this context scientists and plant breeders must prepare for climate change by identifying genomic sequences and notably gene regulatory elements (RE) responsible for stress-tolerance and mechanistically understand how they allow plants to overcome detrimental environments. To meet this challenge, in the 4D-HEAT project, we propose to decipher mechanisms driving the dynamics of enhancer promoter contacts in response to heat stress. This highly innovative and timely project integrates linear epigenome (1D), transcriptome data (2D) and chromatin architecture (3D) with a temporal dimension (4D) into a comprehensive approach to understand the chromatin-based regulation of enhancer promoter contact and how this can impact gene regulation in crops.

Project coordinator

Monsieur Moussa Benhamed (Université Paris-Saclay / Institut des Sciences des Plantes de Paris Saclay)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


GBF Génomique et Biotechnologie des Fruits
UPSaclay / IPS2 Université Paris-Saclay / Institut des Sciences des Plantes de Paris Saclay
GReD Génétique Reproduction et Développement
UPSaclay / IPS2 Université Paris-Saclay / Institut des Sciences des Plantes de Paris Saclay

Help of the ANR 579,580 euros
Beginning and duration of the scientific project: January 2022 - 48 Months

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