Artificial Cuticule : Hemipteran stylet and its microbial surface interactions modeled by cuticle-biomimetic polymer assemblage – ArtiCute
Vector biology is an essential field within global health. For plant pathogens and their arthropod vectors, a major mode of transmission involves a very early but specific interaction with peculiar cuticular surfaces of the vector. These mechanisms nevertheless remain poorly understood but those of a few viral/bacterial models; they might involve either protein receptors of the stylet acrostyle (virus), or cibarial µterritories (bacteria). A reliable platform for in vitro interaction with native chitin-protein assemblies is currently lacking, and this is the subject of the ANR ArtiCute (Artificial Biomimetic Cuticles). These protein arrays should eventually allow a medium throughput screening of candidate proteins downstream of genomic annotations and quick a priori or experimental sorting. Validation work will concern our 2 hemipteran models and their viral (CaMV & TuMV) or bacterial (Dickeya dadantii & Serratia symbiotica) partners, as well as potential interaction blocking agents.
Monsieur Yvan Rahbé (MICROBIOLOGIE, ADAPTATION ET PATHOGENIE)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
MAP MICROBIOLOGIE, ADAPTATION ET PATHOGENIE
PHIM Plant Health Institute of Montpellier
IMP INGENIERIE DES MATERIAUX POLYMERES
Help of the ANR 400,044 euros
Beginning and duration of the scientific project: January 2022 - 36 Months