A Multimaterial and multicellular Bioprinting platform to elaborate advanced models of microenvironments – PrinTiss

This project aims at developing a multi-material bioprinting platform involving microfluidics and integrated optics concepts to create heterogenous 3D models of tissues. The system will be adapted for the 3D assembly of different biological building blocks consisting of biomaterials mimicking the extracellular matrix, individual cells, and spheroids or organoids with a placement accuracy down to the cell scale. Our ambition is to demonstrate the ability of the Printiss approach to fabricate controlled and reproducible models of tissues reproducing physiological or physiopathological features of the in vivo microenvironment, permitting their evolution towards a functional state. These models will allow one to explore cell-spheroid interactions as well as tissue-material interactions from the millimeter to the centimeter scales. We propose to apply this technology to fundamental questions related to the pre-vascularization of adipose tissue as a soft tissue model.