Multimodal nanoprobes for high resolution and high penetration imaging – DARE-DeepAndResolved

The combination of nano-bio technology with innovative therapeutic approaches have led to many successful proof-of-principle demonstrations in the last decades, which foster the hope for new diagnostic/therapeutic strategies for different types of diseases. However, the translation of this approach from the laboratory bench into clinical practice has often proven unproductive. An important reason for this failure is the lack of well characterized and robustly reproducible nano-probes exerting simultaneously several contrast mechanisms making them amenable both for high resolution (optical) and high penetration (MRI, CTI) imaging techniques. In this project, building up on our previous experience on Harmonic Nanoparticles, we devise to provide and characterize by state-of-the-art techniques a new nanoplatform which incorporates in its core several optical mechanisms (multi-order nonlinear mixing and NIR fluorescence) and which can be also detected by magnetic and CT instrumentation.