CE07 - Chimie moléculaire

Adaptive and coopErative helical Catalysts – AdECat

Submission summary

Asymmetric bifunctional catalysts, which integrate separate catalytic moieties and functional groups in the same chiral molecular framework, appear as highly efficient for the preparation of key products. However, their covalent backbone is hardly tunable which considerably limits their scope. Adaptive and cooperative helical catalysts (AdECats) will offer a unique strategy to tune the nature and control the distance between catalytic and functional groups, exacerbating their propensity to activate challenging substrates in a cooperative manner. Co-assembly between a ligand monomer, a functionalized monomer and a chiral inducer will generate a library of AdECats. Gold-, copper- and rhodium-catalyzed reactions will be targeted for which conventional catalysts perform poorly. Likewise, the selectivity of AdECats will be switched during the ring-opening polymerization of cyclic esters in order to access multi-stereoblock aliphatic polyesters.

Project coordination

MATTHIEU RAYNAL (Institut Parisien de Chimie Moléculaire)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


IPCM Institut Parisien de Chimie Moléculaire
IPCM Institut Parisien de Chimie Moléculaire
Universitat de Barcelona / Department of Inorganic and Organic Chemistry

Help of the ANR 478,576 euros
Beginning and duration of the scientific project: March 2022 - 48 Months

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