CE06 - Polymères, composites, physique et chimie de la matière molle, procédés

Long-circulating Janus nanorods to inhibit amyloid aggregation and toxicity – JAROD

Submission summary

The misfolding and aggregation of peptides and proteins into beta-sheet-enriched amyloid fibrils are associated with severe human diseases including Alzheimer’s disease, spongiform encephalitis, type 2 diabetes and Parkinson’s disease. The objective of this proposal is to elaborate and test smart nanoparticles that will be able to clean the blood from aberrant peptides and thus avoid their aggregation. These nanoparticles are Janus nanorods with two faces that can be functionalized differently and independently. One face will be functionalized to selectively interact with and trap the soluble forms of aberrant amyloid peptides, and the other face will be functionalized to interact with serum albumin (in order to increase circulation time and orient the amyloid peptide biodistribution to the liver for destruction).

Project coordination

Laurent BOUTEILLER (Institut Parisien de Chimie Moléculaire)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

UPSaclay BioCIS Université Paris Saclay, Biomolécules : Conception, Isolement, Synthèse
IMMM INSTITUT DES MOLÉCULES ET MATÉRIAUX DU MANS
IGPS Institut Galien Paris Sud
IPCM Institut Parisien de Chimie Moléculaire

Help of the ANR 595,238 euros
Beginning and duration of the scientific project: - 48 Months

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