CE20 - Biologie des animaux, des organismes photosynthétiques et des microorganismes

Operon-based Discovery of carbohydrate-active Enzymes – ODE

Submission summary

The aim of this project is to boost the discovery of enzyme families involved in glycan breakdown. Glycan breakdown is central to human and animal nutrition, fungal/plant-cell wall remodeling, host-pathogen interactions, biomass reutilization, etc.. However, the discovery of novel enzyme families is strongly limited by the selection and characterization of a target by independent experimental research groups. The present project will provide a large-scale computational solution by taking advantage of annotation/data accumulated in CAZy and PULDB (for Carbohydrate-Active enZyme and Polysaccharide Utilization Loci databases) to perform comparative genomics approaches. Guided by the genomic context, protein families of unknown function that are the most likely to become carbohydrate-active enzyme families will be identified, and their substrate category predicted. To support our prediction and concept, experimental validation will be conducted on selected cases.

Project coordination

Nicolas TERRAPON (Architecture et fonction des macromolécules biologiques)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

AFMB Architecture et fonction des macromolécules biologiques

Help of the ANR 350,568 euros
Beginning and duration of the scientific project: December 2020 - 36 Months

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