CE20 - Biologie des animaux, des organismes photosynthétiques et des microorganismes

Uncovering the virome of archaeal methanogens – VIROMET

Submission summary

Methanogenic archaea are phylogenetically diverse, ancient and environmentally widespread. They are common inhabitants of the gastrointestinal tract of humans and other animals, and produce methane, a potent green-house gas, as a metabolic by-product. Despite the ecological importance and diversity of methanogens, their viruses are virtually unknown. The aim of the VIRMET project is to perform a comprehensive characterization of the virome associated with methanogens using state-of-the-art computational and experimental approaches. We will use a targeted strategy to identify and compare methanogenic virus genomes by using publicly available and in-house faecal viromes and metagenomes. In parallel, we will isolate viruses infecting the main human-associated methanogens and characterize their effect on host growth and physiology. This innovative and pioneering project should answer fundamental questions about the diversity, evolution and impact of the methanoarchaeal virome.

Project coordination

Simonetta Gribaldo (Unité Evolutionary Biology of the Microbial Cell)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ARVIR Virologie des Archées
EBMC Unité Evolutionary Biology of the Microbial Cell

Help of the ANR 521,626 euros
Beginning and duration of the scientific project: November 2020 - 48 Months

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