CE07 - Chimie moléculaire

The Golden Age of Biocatalysis: Combining Au(I) and enzymes – BiAuCat

Submission summary

Biocatalysis using enzymes for synthetic purpose has become accessible to synthetic chemists. Recently, the ?-transaminases, imine reductases or reductive aminases have enlarged the way to conceive the synthesis of chiral secondary amines and are even used at the industrial level. Among other enzymes, the so-called “Radical SAM enzymes” have emerged as a novel class of biocatalysts able to catalyze unprecedented chemical transformations, such as the alkylation of a variety of sp3- and sp2- carbon atoms, including the selective methylation at the position 2 of indole derivatives.

Cationic gold complexes are also efficient catalysts for the creation of C-C bonds. The spirocyclization of 2,3-disubstituted indoles tethered to unsaturations has emerged as a powerful approach for the access to potentially bioactive chiral spirocycles.

The BiAuCat project aims at combining the direct and selective functionalization of various indolic compounds using reductive aminases and/or radical SAM enzymes with the gold-catalyzed spirocyclizations using (chiral) Au(I) complexes. This innovative strategy will pave the way to new chiral spirocyclic derivatives through a sustainable approach.

Project coordination

Xavier GUINCHARD (Centre National Recherche Scientifique)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CNRS - ICSN Centre National Recherche Scientifique
INRAE (MICALIS) Institut national de recherche pour l’agriculture, l’alimentation et l’environnement

Help of the ANR 486,725 euros
Beginning and duration of the scientific project: December 2020 - 48 Months

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