CE07 - Chimie moléculaire

Glycosynthase-mediated synthesis of bacterial cell wall mimics – Glyco_SWIM

Submission summary

Antibiotic resistance is a major global public health issue and a WHO priority since 2015. The majority of current antibiotics inhibit the biosynthesis of peptidoglycan, an essential structural component of the bacterial wall. The fight against antibiotic resistance thus requires a better understanding of the proteins involved in the biosynthesis of peptidoglycan. This study is hampered by the lack of well-defined ligands allowing a fine structural and mechanistic analysis. Glyco_SWIM aims to develop an innovative and convenient access to peptidoglycan oligomers of well-defined size and structure. The originality will lie in the use of an enzyme obtained molecular engineering capable of polymerizing a simple disaccharide precursor. The bacterial wall mimics thus obtained will allow a fine analysis by X-ray crystallography, nuclear magnetic resonance and enzymology of major proteins acting on the peptidoglycan.

Project coordination

Sebastien FORT (CENTRE DE RECHERCHES SUR LES MACROMOLECULES VEGETALES)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IBS INSTITUT DE BIOLOGIE STRUCTURALE
CERMAV CENTRE DE RECHERCHES SUR LES MACROMOLECULES VEGETALES

Help of the ANR 304,325 euros
Beginning and duration of the scientific project: January 2021 - 36 Months

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