CE07 - Chimie moléculaire

Gem-Binucleophilic Linchpins for Orthogonal Multicomponent Asymmetric Reactions – BILIOMAR

Submission summary

Multicomponent reactions (MCRs) represent an important trend in the development of more and more eco-compatible synthetic procedures. Indeed, the assembly of at least three substrates in a single step allows the preparation of functionalized small molecules or building blocks with high atom economies in a straightforward manner. Historically, the development of MCRs is closely related to the use of specific synthetic linchpins, which are densely functionalized species enabling the course of domino processes. Whereas almost all these reagents behave either as electrophile/nucleophile or as bielectrophiles, the use of binucleophilic carbon species has received much less attention. The present project aims at introducing gem-binucleophilic linchpins in the elaboration of asymmetric MCRs. In the context of eco-compatible chemistry, these approaches will focus on the use of environmentally benign metallic elements or metalloids such as boron, silicon or zinc.

Project coordination

Le Gall Erwan (Institut de Chimie et des Matériaux Paris-Est)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


ICMPE Institut de Chimie et des Matériaux Paris-Est
IPCM Institut Parisien de Chimie Moléculaire

Help of the ANR 373,572 euros
Beginning and duration of the scientific project: October 2020 - 48 Months

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