The Observation of low Gyromagnetic ratio nuclei in biomaterial Environments Through Hyperpolarization Enhanced magnetic Resonance – TOGETHER
Elements such as Ca and Mg are crucial in many synthetic and natural materials, including bones and teeth. The intrinsic structural
complexity of these materials calls for the development of original and advanced characterization techniques. New and promising
preliminary results obtained by 43Ca DNP (Dynamic Nuclear Polarization)-enhanced NMR (Nuclear Magnetic Resonance) at natural
abundance (0.14 %) have shown that an unprecedented description of chemical environments around Ca atoms can be reached
(distinction of surface and core sites in nanomaterials), circumventing the ultra-low sensitivity of 43Ca! Thus, the objectives of the
project are: (i) methodological development of the DNP-NMR experiment, (ii) optimisation of this new technique for the description of
Ca and Mg environments in synthetic biomaterials, (iii) in-depth study by 43Ca and 25Mg DNP-NMR of bones of normal and genetically
engineered mice, in view of expanding our understanding of human bone pathologies.
Project coordination
Christel GERVAIS (Chimie de la Matière Condensée de Paris)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
INSERM-CPTP INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
LCMCP Chimie de la Matière Condensée de Paris
MEM Modélisation et Exploration des Matériaux
ICGM Institut de chimie moléculaire et des matériaux - Institut Charles Gerhardt Montpellier
Help of the ANR 699,748 euros
Beginning and duration of the scientific project:
May 2020
- 42 Months
