Engineering Nanohybrids to produce Super-Magnetic and Functional Stem Cells for Cardiac Tissue Engineering – SuperMagStemCells
The goal of the SuperMagStemCells project is to produce cardiac-primed engineered tissues, starting from magnetic stem cells, and using remote magnets for tissue formation and stimulation. To do so, it must resolve the impact that magnetic nanoparticles may have on stem cells functions, especially at high intracellular magnetic dose, probably linked to the intracellular release of degradation products. Our main hypothesis is that shielding the magnetic core from degradation will prevent any biological impact on stem cells. We will provide non-degrading magnetic nanoparticles by designing nanohybrids featuring a magnetic core protected by a continuous gold shell. A specific attention will be paid to the optimization of the magnetic properties of the core, to generate in fine ultra-magnetic@gold nanohybrids. A parallel approach will be explored to escape toxicity through an unprecedented biosynthesis route we have just reported in stem cells. The final goal will be to deliver (super)magnetic and functional stem cells.
In this context, the three objectives of SuperMagStemCells are: (1) to develop (ultra)magnetic nanohybrids (magnetic@gold) that would be totally protected from the harsh intracellular environment; (2) to fully understand all potential long-term risks in iron oxide long-term intracellular degradation, and to explore a biosynthetic approach to make the stem cells produce their own, inherently biocompatible, magnetic nanoparticles; and (3) to produce and test in vivo magnetically-organized and stimulated stem-cells-based tissue substitutes for cardiac tissue regeneration.
Madame Claire Wilhelm (Institut Curie)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
MSC Laboratoire Matière et Systèmes Complexes
PHENIX PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX
IC Institut Curie
LVTS - UP13 Laboratoire de recherche vasculaire translationnelle
B2A Adaptation Biologique et Vieillissement
Help of the ANR 845,337 euros
Beginning and duration of the scientific project: March 2020 - 48 Months