CE09 - Nanomatériaux et nanotechnologies pour les produits du futur

Smart Coating for Inorganic Nanoparticules – SmartNanoCoat

Submission summary

In the context of the research in innovative and efficient systems for both treating and detecting diseases, NanoParticles (NPs), because of their nanoscale size, offer the opportunity to: i) improve in vivo pharmacokinetic by extending circulation time and ii) to modify biodistribution by targeting diseased tissues. However, while many inorganic NPs have been identified as promising since the 90’s, less than 10 are nowadays approved for patient healthcare.
Toxicity issues related to colloidal instability in biological media and functionalization control/characterization difficulties are important unsolved drawbacks that remain serious bottlenecks in the development of inorganic NPs for biomedical applications.
To overcome these issues, we propose the development of new multidentate polymers with a perfectly defined structure to coat NPs in a highly stable and stealth manner. These multi-anchoring polymers carrying biocompatible moieties increase the avidity of the ligands for the NPs surface while conferring stealth and colloidal dispersion in biological media. In this project, we will explore an innovative approach to design and synthesize multidentate functionalized peptides, before validating their potential to coat inorganic NPs for biomedical purposes. This strategy is modular and tunable, allowing a rational design of inorganic NPs coating depending on the desired properties of the final NPs. In this ANR project, we plan to show the potential of this new strategy on very promising inorganic NPs, Gold NanoRods (GNRs). These rod-like gold NPs are especially attractive, due to their unique optical properties and potential applications in functional nanodevices thanks to photoacoustic, radio-enhancer or photothermal properties. This project, going from building block synthesis to preliminary in vivo evaluations will pave the way to the development of GNRs as targeted nanomedicines.
Considering the promising potential of inorganic nanoparticles for biomedical uses, this project will have a broad incidence in the field of nanomedicine allowing targeted inorganic NPs to reach the clinic and will contribute to develop better medical solutions in the foreseeable future.

Project coordination

Stéphanie Deville-Foillard (Institut de Chimie des Substances Naturelles)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICSN Institut de Chimie des Substances Naturelles

Help of the ANR 249,518 euros
Beginning and duration of the scientific project: January 2019 - 36 Months

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