CE09 - Nanomatériaux et nanotechnologies pour les produits du futur

Prussian blue nanoparticles for theranostics – NANOBLUE

Submission summary

Prussian blue (BP) nanoparticles (NPs) doped with manganese are particularly interesting for theranostics. Indeed, these NPs have remarkable properties as contrast agents in magnetic resonance imaging and an exceptional photothermal conversion effect which means that these NPs can cause a localized temperature rise when subjected to irradiation in the near infrared; area of the spectrum adapted to various applications in the biomedical field. Rheumatoid arthritis is an inflammatory disease related to the anarchic activation of macrophages. These excessively recruited macrophages at the site of inflammation (synovium) are responsible for the matrix degradation and joint erosion. The objective of this project is twofold: to develop manganese-doped PB NPs with optimized properties and to demonstrate the concept of their use for the treatment of rheumatoid arthritis.

Project coordination

Yannick GUARI (Institut de chimie moléculaire et des matériaux - Institut Charles Gerhardt Montpellier)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICGM Institut de chimie moléculaire et des matériaux - Institut Charles Gerhardt Montpellier
IBMM Institut des Biomolécules Max Mousseron
CNRS-L2C Laboratoire Charles Coulomb

Help of the ANR 399,214 euros
Beginning and duration of the scientific project: September 2018 - 42 Months

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