Oligosaccharidic (multi)block copolymers with tunable composition and properties – OLIBLOCK
The main objective of the project is to widen the possibilities of creating new chemical structures from oligosaccharide blocks. Polysaccharides are very abundant natural polymers, inexpensive, renewable, stable, and modifiable hydrophilic biopolymers that have biological and chemical properties such as non-toxicity, biocompatibility, biodegradability, polyfunctionality, high chemical reactivity, chirality, chelation and adsorption capacities. However, natural polysaccharides often exhibit solubility, processability, and feasibility issues with variable extends depending on the type of polysaccharide, causing difficulty in employing them in a wide variety of applications. In this project, we will prepare and study the properties of a new class of multiblock copolymers based exclusively on the assembly of oligosaccharides carrying different functionalities and thus varying properties. Structurally defined diazido (AA) and dipropargyl (BB) oligosaccharide monomers will be synthesized from cyclodextrins by selective ring opening followed by terminal modification. Side-chain functionalization will be performed on diazido or dipropargyl blocks, in order to obtain and combine hydrophobic/hydrophilic blocks, and anionic/cationic/neutral blocks especially through the introduction of biosourced side-groups. Complementary diazide and dialkyne oligosaccharide-based monomers containing different side-chain functionalization will be copolymerized by AA + BB copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) mediated step growth polymerization. Post-polymerization modifications will also be performed through N-alkylation of the resulting poly(1,2,3-triazole)s to yield the corresponding poly(1,2,3-triazolium)s. Besides, anion exchange with biosourced salts will be an additional mean to provide highly functional biosourced saccharide-based materials with original structures and properties. After preparation and thorough characterization, we will relate the structure of the obtained multiblock copolymers with their physical and physico-chemical properties in solution and in bulk as well as their mechanical and processing properties. The preparation of most promising polymers will be scaled-up using green routes for monomer synthesis and functionalization to investigate the most relevant applications based on their peculiar properties, i.e. formation of nanoparticles, encapsulation/release properties, stabilizers for cosmetics, stabilizers/dispersants of renewable colloids, e.g. nanocellulose, chitin or starch nanoparticles.
Monsieur José Kovensky (LABORATOIRE DE GLYCOCHIMIE, DES ANTIMICROBIENS ET DES AGRORESSOURCES (LG2A))
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
IMP UNIVERSITE LYON 1 CLAUDE BERNARD
LG2A UMR 7378 LABORATOIRE DE GLYCOCHIMIE, DES ANTIMICROBIENS ET DES AGRORESSOURCES (LG2A)
Help of the ANR 366,029 euros
Beginning and duration of the scientific project: October 2017 - 48 Months