DS0405 -

CO-EVOLUTION OF PROPHAGE AND BACTERIAL GENOMES: PROPHAGE COOPTATION and LYSOGENIC CONVERSION in SALMONELLA – Salmo_prophages

Submission summary


Temperate bacteriophages are bacterial viruses that can integrate their genome into their hosts. In the lysogenic state they are transmitted vertically without any requirement for a lytic cycle, as long as no stressful conditions are encountered. Under such a state, they provide new genetic material and thus influence the host genotype and phenotype, in particular through the acquisition of virulence and adaptive traits that are found in many human pathogens. Phage-encoded virulence factors influence bacterial pathogenicity in many different ways including increased fitness under infectious conditions. The Salmo_Prophages project combines large-scale bioinformatics to up to date molecular genetics to characterize prophage-encoded functions cooptation as well as the influence of lysogeny on Salmonella species genotypes and phenotypes. These themes are established and recognized as major expertise of our consortium. Together, this project based on the study of bacteriophage mediated horizontal gene transfer and host-phage genomes coevolution brings valuable perspectives to develop new diagnosis tools and treatment of infectious diseases.

Project coordination

Mireille Ansaldi (Laboratoire de Chimie Bactérienne)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IP / CNRS UMR 3525 INSTITUT PASTEUR / Unité de génomique évolutive des microbes
CNRS DR12_LCB Laboratoire de Chimie Bactérienne

Help of the ANR 444,115 euros
Beginning and duration of the scientific project: December 2016 - 48 Months

Useful links

Explorez notre base de projets financés

 

 

ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter