DS0305 -

Biomimetic cell membrane guided by 3D-DNA origami nanostrutures. – MembraneDNAorigami

Submission summary

Membrane proteins (MPs) help coordinate pretty much everything a cell does, indeed, about 50% of approved therapeutics target MPs. However, our understanding of MPs molecular mechanisms is still in its infancy. This significant gap in our knowledge and industrial applications is partly due to the slow pace of development of experimental tools for the investigation of MPs. The difficult chemical nature of MPs impede drastically further studies and economic-valorizations. Today, the challenge is to step beyond the most simple and straightforward in vitro mimics of the cell membrane, and create templates systems that more closely reproduce the conditions in vivo. We propose to engineer cell-free membrane with a high level of control by artificially placing MPs components on a programmable DNA nano-template. These such man-made nanodevices will be direct use for drug-screening, self-assembled nano-bioreactor, biosensing, biophysics, on-demand drug delivery, and energy harvesting.

Project coordination

Gaëtan BELLOT (Centre de Biochimie Structurale)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CBS - INSERM U1054 Centre de Biochimie Structurale

Help of the ANR 231,940 euros
Beginning and duration of the scientific project: February 2017 - 36 Months

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