DS10 - Défi des autres savoirs


Submission summary

The bioorthogonal and click chemistry toolbox provides a set of reliable chemical reactions enabling the chemoselective covalent bond formation between two chemical entities without interfering with other existing (bio)functionalities. In the space of a decade, these transformations have dramatically gained importance from Life Sciences to Environmental or Material Sciences. Due to an increasing demand for effective and modular accesses to complex (bio)molecular architectures, the development of a “second generation” of click reactions is envisioned, based on innovative successive bioorthogonal reactions. The usefulness of this strategy will be demonstrated in kinetic target-guided synthesis (KTGS), a promising alternative to high throughput screening, which still suffers from severe limitations (i.e. self-poisoning of the biocatalyst) that dramatically hampers its routine use in both academic and R&D environment.

Project coordination

Cyrille Sabot (Laboratoire de Chimie Organique et Analytique Université de Rouen)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


COBRA Laboratoire de Chimie Organique et Analytique Université de Rouen

Help of the ANR 164,320 euros
Beginning and duration of the scientific project: December 2016 - 48 Months

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