Pulmonary Inflammation Diseases Imaging via their Enzyme Activities with Overhauser-enhanced MRI and Line-shifting Nitroxide Substrates – PULMOZYMAGE
Lungs inflammatory diseases such as COPD are the cause of 2.5 M death worldwide. These diseases have in common a high influx of
neutrophils that secrete proteases responsible for the progressive loss of lungs function. To date there is no method able to assess
lungs enzyme activity in vivo. Such a method would allow an early diagnostic of any protease/inhibitor imbalance long before the
detection of pulmonary lesions by anatomical imaging methods. Lungs function could thus be preserved with protease inhibitors. We
propose a new proteolytic activity imaging method for the lungs using Overhauser-enhanced MRI (OMRI). We will take advantage of
a world unique prototype device and of recently synthesized contrast agents. Method validation will be conducted with mouse models
of emphysema and cystic fibrosis.
Project coordination
Philippe MELLET (Centre de Résonance Magnétique des Systèmes Biologiques)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
RMSB UMR CNRS 5536 Centre de Résonance Magnétique des Systèmes Biologiques
UMR CNRS 7273 Institut de Chimie Radicalaire
PI3 Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques
Help of the ANR 609,821 euros
Beginning and duration of the scientific project:
February 2016
- 48 Months