DS0403 - Exploration des systèmes et organes leur fonctionnement normal et pathologique : physiologie, physiopathologie, vieillissement

H3K27 methylation : regulation and roles in cartilage – EpiCart

Submission summary

For a long time, epigenetic marks were considered as irreversible. In particular, it was thought that once methylated, histones could not be demethylated. It is now admitted that these epigenetic marks are tightly regulated and control numerous cell processes such as differentiation, gene regulation, development, or carcinogenesis. Regarding the physiology of cartilage, the role of epigenetic regulation is still largely unknown. However, recent studies show a critical role of the epigenome in the regulation of the chondrocyte phenotype and in the development of cartilage diseases (osteoarthritis, arthritis…). The objective of this project is to identify the roles of the methylation on the lysine 27 of histone H3 (H3K27) in cartilage development and joint diseases. The results should permit to improve our knowledge on epigenetics in cartilage, and to determine whether the methylation of H3K27 could be a potential target for pharmacological intervention in the treatment of osteoarthritis and possibly other arthritic diseases.

Project coordination

Catherine BAUGE (Microenvironnement cellulaire et pathologies - MILPAT)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

EA4652 Microenvironnement cellulaire et pathologies - MILPAT

Help of the ANR 210,080 euros
Beginning and duration of the scientific project: September 2015 - 42 Months

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