DS0404 - Innovation biomédicale

Hearing in Time – HEART

Submission summary

Information about sounds, including speech, is conveyed in the auditory system via: (i) the patterns of envelope fluctuation (E) and (ii) the detailed temporal waveform (temporal fine structure, TFS) in individual frequency bands. The relative importance of E and TFS information is poorly understood. Nor it is clear how the use of E and TFS is affected by cochlear damage. We will clarify these issues using a multi-disciplinary approach combining psychophysical, speech perceptual and physiological measurements with the development of models of the underlying processes. Psychophysical and speech perceptual measurements will be conducted with normal-hearing and hearing-impaired human subjects, using novel speech-processing algorithms (vocoders) and a novel method attempting to assess the contribution of low level, sensory factors while limiting the influence of high-level (decisional) factors. The models will include the first and last stage of the auditory brainstem i.e. the cochlear nucleus (CN) and the Inferior Colliculus (IC), and physiological measurements will be made in the CN and IC of both normal-hearing and hearing-impaired animals. The results will clarify the effects of cochlear hearing loss on the representation of E and TFS in the brainstem and will clarify the relative importance of E and TFS information for the perception of speech in background sounds. The research will lead to the development of diagnostic tests and to the design of more effective hearing aids.

Project coordination

Christian LORENZI (Laboratoire des Systèmes Perceptifs)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


Cambridge University Department of Physiology, Development and Neuroscience
Cambridge University Department of Experimental Psychology
LSP - Ecole normale supérieure Laboratoire des Systèmes Perceptifs
CNPS Centre de neurosciences Paris-Sud

Help of the ANR 261,248 euros
Beginning and duration of the scientific project: September 2014 - 36 Months

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