NEURON 2013 - Appel à Projets Transnational dans le cadre de l'ERA-NET NEURON II sur les Maladies Mentales - Volet international de l’AAP SAMENTA 2013

COCAINE ADDICTION: A TRANSLATIONAL STUDY TO IDENTIFY AND CHARACTERIZE DYSFUNCTIONAL NEURONAL NETWORKS – COCADDICT

Submission summary

Only some people who try cocaine (15 - 20%) become severely addicted, continuing to use the drug despite
accumulating negative consequences. Unfortunately, we know little about why some people lose control of
cocaine use, and medications to treat cocaine addiction have yet to be discovered. To address these issues, the
present group will study sequential stages of the addiction process in individuals with varying risk for addiction.
The studies will benefit from coordinated research streams both in cocaine users and in a high face validity animal
model. By exploiting new brain imaging methods, we will dissociate alterations that are related to addiction from
those that are not. By using novel brain activation techniques, we will identify the relevant neurochemistry within
these circuits, and determine whether the addiction-related neural changes can be reversed in experimental
animals. Together, the studies will help to identify neurobiological trajectories into addictive behaviour and
potential treatment targets.

Project coordination

Véronique Deroche-Gamonet (Institut Francois Magendie - INSERM)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

INSERM Institut François Magendie - INSERM
INSERM Institut Francois Magendie - INSERM

Help of the ANR 273,280 euros
Beginning and duration of the scientific project: May 2014 - 36 Months

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