volumic accelerated reconstruction for X-ray early osteoarthritis diagnosis lowering dose and cost – VOXELO

Osteoarthritis is an important public health issue. For humanistic and economical reasons, there are many reasons to identify and treat OA as early as possible. Knee Osteoarthritis (OA) is the most common rheumatic disorder. The most used methods are plain X-rays and Magnetic Resonance Imaging. New therapies to treat cartilage disease are under development, this progress requires the development of diagnostic methods non-invasive, low irradiating, simple, in particular, capable of quantifying changes in joint space. The use of innovative methods of three dimensional (3D) tomographic reconstruction based on an X-ray conical beam with only few views is a challenge. This new technology is likely to decrease the radiation level and can be potentially exploited in clinical routine for diagnosis and monitoring. Based on this new modality, 3D Quantitative analysis will potentially be developped for early OA diagnosis, especially joint space narrowing and textural analysis of the sub-chondral bone. For that, we propose a preclinical study of an original 3D volumetric reconstruction algorithm with as the main strengths to necessitate less than 32 views (the objective is 16 views) and the integration of physical phenomena in the process. This will also need the establishment of a system of calculating acceleration. The images obtained with voxel size of 150 ?m3 will be compared to high resolution peripheral quantitative computed tomography images (XtremCT Scanco®) which will serve as reference. The knee is used as a test object but new developments will follow in other applications such as orthopedic surgery navigation, the dentistry but also for thoracic and vascular domains.