BIOimpedance and Temperature Organ Monitoring – BIOTOM

This project aims, in a context of organ avilabily shortage and the desire to control expend on public health, increase the number of endpoints on a graft to optimize the processing conditions, and give the possibility to delegate the explantation of organs to a team without mobilize and move precociously the team receiving center.

Given the importance of the shortage of grafts, the Agency for Biomedicine (ABM) promotes the expansion of indications for organ transplant Non-Heart Beating Donors (NHBD), which also broadens the risk to the quality of the organ and its preservation.

During his transplant, an organ is submit to conditions different of its normal physiological context (ischemia, cooling, ...), which induces stress and trauma that may affect the restoration of its function after transplantation.
Continuous monitoring of organ physiological status associated to its temperature, would allow a better understing of the evolution of the conservation status of the organ.

Learning about graft and its behavior during the transplantation period (strating from the explantation phase, until the reperfusion phase after tranplantation / preservation) will allow a better understing of the function retrieval and therefore better sizing treatment post-transplant (dialysis, medication, ...).

In addition, as part of cardiac and liver transplantation among other things, we are at a time when every team is searching the pooling of harvest. The harvest delegation would be possible by the development of a device providing complete traceability as well as monitoring the quality of the organ which would save the samplers fatigue of travel and allow the public health system to reduce expenses on logistics costs. The aim of this project is the development of such a device.