PCV - Programme interdiciplinaire en physique et chimie du vivant

Mesoscopic Origins of Force Generation and Transmission in Tissues – MeSoForTiss

Submission summary

The morphogenesis of developing embryos and organs relies on cells‚ abilities to change shape and to remodel their contacts with other cells. These behaviors stem at the celular level from interplay between the cortical tension and adhesion. In this context, we aim at elucidating how cortical actin network and adhesion molecules (E-cadherin) are spatially organized at cell boundaries in a tissue, how their spatial order changes during contact remodelling, and probe some of their mechanical properties. To do so we will develop a microscope with a resolution of a few tens of nm (~50 nm in the three dimensions) and use a set of experimental tools which are able to probe dynamic changes of molecular order and force distribution. To tackle these questions, we will study the early epithelium of Drosophila embryos, which is amenable to powerful optical methods for imaging and mechanical perturbation, as well as to biochemical perturbations and genetic functional tests.

Project coordination

Pierre François LENNE (Organisme de recherche)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

Help of the ANR 325,000 euros
Beginning and duration of the scientific project: - 36 Months

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