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DNA-branched Ruthenium Junctions and their DNA-based Nanoscale Assemblies – DNaRu

Submission summary

DNA is a particularly promising candidate to serve as a construction material in nanosciences. Despite its simplicity, the outstanding specificity of the A-T and G-C Watson-Crick hydrogen-bonding interactions enables the creation of constructions with a predictable structure and even molecular machines. Our project is based on DNA recognition properties to synthesize selectively linear, 2D and 3D nanoscale assemblies and well-controlled metal organizations. For that, a series of DNA-branched ruthenium junctions is realized. Tris-bipyridyl ruthenium complexes were chosen for their almost perfect octahedral coordination geometry and for the opportunity to incorporate into them various number of DNA single strands. The rigidity of these building blocks and the well-known orientation of their DNA arms allow, after DNA hybridization, the control of their spatial locations. Our strategy consists in using the copper-catalyzed Huisgen cycloaddition reaction of alkyne and azide (so-called "click chemistry" or "click reaction") to synthesize a family of ruthenium complexes bearing one to six linear or branched DNA strands. Two synthetic pathways are developed depending on the functions introduced in DNA and ruthenium complexes. Indeed, metallic entities with azide or alkyne functions are synthesized and vice versa for modified oligonucleotides. Click chemistry coupling of these fragments affords a family of twenty four DNA-branched ruthenium junctions. DNA hybridization of different combinations of these building blocks generates well-controlled linear, 2D and 3D DNA-Ruthenium nanostructures. It also provides access to libraries of precisely located metal groups. The ability to organize metals remains a central challenge in nanosciences and our strategy leads to new opportunities and advances in this field by the development of new tools for well-controlled metal organization.

Project coordination

Valérie SARTOR (Organisme de recherche)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


Help of the ANR 177,085 euros
Beginning and duration of the scientific project: - 36 Months

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