BLANC - Blanc

Biological Growth Medium Integrity Diagnoses using bi -modality tomographies – BioGMID

Biological Growth Medium Integrity Diagnoses using bi -modality tomographies

.

scientific background and objectives

Long bones and woods are biological and natural growth-medium with similarities related to their structure. These mediums are anisotropic, and are generally modelled as transverse isotropic for human bones and/or orthotropic for animal bones and wood. These mediums are adapting itself in to the environmental strength, and obviously in to the age. These changes result in variations that are much more complex than anisotropy. Mechanical properties in any one principal direction vary in the growth-medium as a result of gradual transition from juvenile to mature material. The study of the quality and of the origin of the dysfunctions is the object for several years of very relevant studies. Today, the ultrasonic method, and associated clinical devices such as echography or Quantitative Ultrasound, is recognized to be very relevant for the study of fractures risk in bone but is in controversy for growth-bone at the juvenile stage. For green wood, numbers of auscultation tools are available and marketed, based on the X-rays or the acoustic wave propagation. Both are referring that in the only density what is not sufficient or not enough precise. An ultrasound measurement suitably combined with an X-ray measurement should allow a qualitative and quantitative high-resolution analysis of the structure. The objective of the project is to propose an efficient and optimized procedure of characterization and cross-sectional imaging of this kind of growth-medium.

The project suggests establishing a method of investigation based on fruitful combination of ultrasound and X-rays measurements. Five tasks are proposed: - The first task consists in modelling efficiently the interaction between ultrasonic wave and the medium. The objective is to explicit the forward problem used in tomography, and thus, understanding the wave complex phenomenas. Underlying is the production of synthetic signal to simulate efficiently a numerical experiment. - The second task aims at defining optimised strategies to the inverse problem of tomography, and at identifying the effective limits for the growth-medium imaging and integrity diagnoses - The third task consist in developing an adapted protocol of 1-dimensional characterisation. Obviously this task is linked with the second; the efficient parameters will be referent in quantitative X-ray and ultrasonic imaging; and therefore linked with the fourth. - The fourth task consists in the conception (and the realization) of a single experimental set-up for growth-medium characterization to determine the mechanical properties of materials and to image it using ultrasonic tomographic method. This last cross-sectional imaging technique will then be fused with a new, and also adapted, scattering X-ray tomography. - The fifth task concerns the signal and image processing. It is mainly a question of implementing methods adapted to the acoustic signals, and of combining the cross-sectional multi-modalities tomographies. The main objective is a comparison of experimental benchmarks.

Expected results

The project will deal thoroughly with the problem of the characterisation and cross-sectional imaging of biological growth-medium. Its objective is to point out clearly an experimental device and protocols, and to propose ways to implement it efficiently to diagnose juvenile long bones and/or regenerating tissues, and green wood integrity. Analysis and modelling the forward problem will result in the comprehension of the origin of the underlying phenomena, which will allow to propose more complex strategies to solve the inverse problem of elastic constraints evaluation and cross-sectional tomographies. The application of the preceding results will thus result in building an experimental circular aperture set-up, able to deal with the coupled problem of low and high frequency non-destructive evaluation and imaging. The definition of this prototype will bring useful elements for starting a technological development (for in situ or in vivo evaluation), possibly following the project. Moreover, the most significant output of the BioGMID project will concern the growth-medium integrity diagnoses, which constitutes a major scientific international challenge. The results of the project will be presented during a seminar organized by the partners of the project, and whose proceedings will be available for the scientific and industrial communities interested in these applications. Main references - P. Grangeat (2002) « La tomographie : fondements mathématiques, imagerie microscopique et imagerie industrielle «, Lavoisier. - E. Seeman, P.D. Delmas (2006) Bone Quality – The Material and Structural Basis of Bone Strength and Fragility – The New England Journal of Medicine, 354; 21, 2250-2261. - V. Bucur (2003) « Nondestructive characterization and imaging of wood «, Springer-Verlag.

.

Long bones and woods are biological and natural growth-medium with similarities related to their structure. These mediums are anisotropic, and are generally modelled as transverse isotropic for human bones and/or orthotropic for animal bones and wood. These mediums are adapting itself in to the environmental strength, and obviously in to the age. These changes result in variations that are much more complex than anisotropy. Mechanical properties in any one principal direction vary in the growth-medium as a result of gradual transition from juvenile to mature material. The study of the quality and of the origin of the dysfunctions is the object for several years of very relevant studies. Today, the ultrasonic method, and associated clinical devices such as echography or Quantitative Ultrasound, is recognized to be very relevant for the study of fractures risk in bone but is in controversy for growth-bone at the juvenile stage. For green wood, numbers of auscultation tools are available and marketed, based on the X-rays or the acoustic wave propagation. Both are referring that in the only density what is not sufficient or not enough precise. An ultrasound measurement suitably combined with an X-ray measurement should allow a qualitative and quantitative high-resolution analysis of the structure. The objective of the project is to propose an efficient and optimized procedure of characterization and cross-sectional imaging of this kind of growth-medium.

The project suggests establishing a method of investigation based on fruitful combination of ultrasound and X-rays measurements. Five tasks are proposed: - The first task consists in modelling efficiently the interaction between ultrasonic wave and the medium. The objective is to explicit the forward problem used in tomography, and thus, understanding the wave complex phenomenas. Underlying is the production of synthetic signal to simulate efficiently a numerical experiment. - The second task aims at defining optimised strategies to the inverse problem of tomography, and at identifying the effective limits for the growth-medium imaging and integrity diagnoses - The third task consist in developing an adapted protocol of 1-dimensional characterisation. Obviously this task is linked with the second; the efficient parameters will be referent in quantitative X-ray and ultrasonic imaging; and therefore linked with the fourth. - The fourth task consists in the conception (and the realization) of a single experimental set-up for growth-medium characterization to determine the mechanical properties of materials and to image it using ultrasonic tomographic method. This last cross-sectional imaging technique will then be fused with a new, and also adapted, scattering X-ray tomography. - The fifth task concerns the signal and image processing. It is mainly a question of implementing methods adapted to the acoustic signals, and of combining the cross-sectional multi-modalities tomographies. The main objective is a comparison of experimental benchmarks.

Project coordination

Philippe LASAYGUES (Organisme de recherche)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

Help of the ANR 380,000 euros
Beginning and duration of the scientific project: - 48 Months

Useful links

Explorez notre base de projets financés

 

 

ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter