Mots-clés : Integrated structural biology; project-based access; high throughput automation; expression systems; sample production; biochemical and biophysical characterization; biomolecular interactions; crystallization; X-ray crystallography; electron microscopy; NMR; optical spectroscopy
The French Infrastructure for Integrated Structural Biology (FRISBI) was created in May 2011 to set up high-end instrumentation in structural biology and make it available to the French and European, academic and private scientific communities. FRISBI is a distributed infrastructure comprising five centres (Strasbourg, Grenoble, Montpellier, Marseille and Paris-Saclay) open since June 2012 for project-based access to cutting-edge instruments and know-how for structural biology; this includes sample preparation and characterization, spectroscopies, X-ray crystallography, NMR and electron microscopy.
Access is open via the FRISBI website (frisbi.eu) and projects are selected according to technical feasibility, scientific impact and availability of resources.
Since the opening of FRISBI, around 8700 user access projects have been performed. Since 2015, FRISBI has established an annual funded access call to contribute towards the costs of user projects. Thanks to the extension of FRISBI funding a seventh funded access call was opened in 2021. FRISBI also has an important role in training, around 2600 users were trained on FRISBI platforms. Also, FRISBI played a central role in launching the first French National training school in structural biology (ReNaFoBis) and through co-organisation of courses, scientific workshops have established relationships with other national and European infrastructures.
In 2019, we set up an “industry” working group with representatives from industry and organized a first meeting in 2020.
Also, FRISBI coordinates national roadmaps to implement new technologies, reinforces the technology transfer between academic research groups and industry for technological developments, biotechnology and therapeutic applications.
FRISBI has become a driving force in France and beyond in integrated structural biology and therefore needs long term support.
L'auteur de ce résumé est le coordinateur du projet, qui est responsable du contenu de ce résumé. L'ANR décline par conséquent toute responsabilité quant à son contenu.
Acronyme projet : FRISBI
Référence projet : 10-INBS-0005
Région du projet : Grand Est
Discipline : 5 - Bio Med
Aide PIA : 35 800 000 €
Début projet : avril 2011
Fin projet : décembre 2024
Coordinateur du projet : Bruno KLAHOLZ
Email : email@example.com
Etablissement coordinateur : CNRS Alsace (Strasbourg)
Partenaire(s) : CNRS Alpes (Grenoble), CNRS délégation Occitanie Est, CNRS Provence Corse (Marseille), CNRS IDF Sud (Gif)