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From uncomplicated alcoholism to Korsakoff’s syndrome: clinical, genetic, neuropsychological and brain examinations – GO-ALCOBRAIN
The main objective of GO-ALCOBRAIN is to facilitate my return to France and to support my integration with the French U923 Inserm Unit. The skills and knowledge I acquired during my PhD thesis and my postdoctoral trainings on alcohol-related cognitive deficits and brain damage are indeed crucial for
ELECTRICAL CONTROL OF CELL POLARIZATION – COELPOCE
Cell polarity plays a key role in regulating cell-cell communication, tissue architecture and development. Both internal and external cues participate in directing polarity and feedback onto each other for robust polarization. One poorly appreciated layer of polarity regulation comes from electroch
ACCREtion and Thermal evolution of Icy Satellites – AccrETiS
The Solar system was formed 4.567 Gyr ago. Just like terrestrial planets, satellites of giant planets (icy satellites) were formed from accumulation of material brought by meteorite impacts These moons were formed within the circumplanetary disk from ice and rock chunks. Differences in composition a
Neural mechanisms of vocal learning in songbird: role of the basal ganglia – SONGLEARN
Vocal learning involves the basal ganglia (BG)-thalamo-cortical network, as do many other complex motor skills. I propose to study the role of the BG-thalamo-cortical loop in sensorimotor learning, focusing on vocal learning as a special case. To this end, I will work on the songbird, one of the few
Radical Events and Life Reconstruction (anthropological approach in the context of India) – RUPTURES
The Ruptures program began in December 2010 at the Centre for South Asian studies, Paris, thanks to a funding from the French national research agency. Its main objective was to provide a platform to reflect upon phenomena of rupture when the existence of individuals or groups becomes radically rede
Role of 5-Fluorouracil in the modulation of anticancer immune responses: Molecular mechanisms and identification of novel therapeutic targets – RFAT
Primary tumors are currently treated by a combination of therapies including, in most cases, surgery, local radiotherapy, and adjuvant chemotherapy. Even when the tumor has apparently been defeated, micrometastases of dormant tumor cells frequently lead to tumor relapse and final therapeutic failure
Response of Corals to Local and Global Stressors: from gametes to adults – R-ECOLOGS
The project R-ECOLOGS aims to better understand the effects of local contamination and temperature on the response of adult corals but also of early life stages. This project will address important knowledge gaps on the response of corals to the effects of local and global stressors and on the influ
Quantum Nano-Optomechanics – Q-NOM
The huge experimental efforts developed over the laser 5 year by several groups in the world have permitted reaching and observing macroscopic mechanical oscillators in their quantum motional ground state. The objective of the project was to go beyond ground state cooling and developing systems perm
Observing functional protein dynamics at atomic resolution by solid-state NMR spectroscopy – ProtDynByNMR
Delineating the relationship between molecular function, and their structure and flexibility is a major goal of current life sciences. Establishing this link between function and motion is particularly difficult for some of the most interesting proteins, such as very large complexes and membrane pro
Carbon monoxide/heterocycle copolymerisation: New catalysts and new biodegradable polymers – NewCatNewBioPol
The ambition of the project is to study and develop more elaborated and efficient ligand systems for this catalytic reaction as well as new organometallic complexes for this important reaction to develop and promote a cheap, efficient and industrially viable methodology for the preparation of biodeg
Molecular Recognition with Urea-based Foldamers : From Anion Receptors to Bioinspired Organocatalysts – UREKAT
Although the project stands primarily in foldamer research, it is characterized by a strong interplay with the field of artificial anion receptors and H-bond mediated organocatalysis. Translating structure information into function certainly represents one of the most fascinating issues in the fiel
Combinatorial Representation Theory – TRC
Use and develop the known combinatorial tools and techniques to solve important problems in representation theory of finite groups. Describe and use new combinatorial methods in other classes of groups, thereby allowing progress in the understanding of their representation theory. Existence of pe
Temperature, dissolved Oxygen and Predator-Prey interactions - Prey distribution Assessment Through Characterization of feeding Habitats of Elephant Seals – TOPP-PATCHES
Global warming affects the accessibility and availability of prey in marine ecosystems . A deepening of the thermocline and an increase in ocean stratification are expected. In addition, the concentration of dissolved oxygen at depth should also decrease. All these changes could affect the horizonta
Two-Color Assisted Nanoquenching for Sub-Lambda Photofabrication – Nanoquenching
Nanofabrication is a key point in the field of nanosciences and nanotechnolgy. The goal is to produce nanostructure typically between 1 and 100 nm which exhibit original chemical and physical properties. The control of this structuration, regarding the structure's dimension and/or the nature of the
Malaria Liver Infection: molecular mechanisms of host cell invasion by Plasmodium sporozoites. – MaLI
The malaria parasite Plasmodium is transmitted by Anopheles mosquitoes, which inject infective forms called sporozoites into the host skin. Motile sporozoites rapidly travel to the liver and invade hepatocytes by forming a parasitophorous vacuole, where they transform into liver stages. After a few
Implementation of Developmental Learning – IDEAL
This project consists of implementing a mechanism of early-stage developmental Learning (Piaget, 1937) in an artificial agent situated in a simulated environment. More precisely, we will implement a mechanism for the agent to autonomously engage in a bottom-up process of hierarchical organization of
sRNA targeted to the mRNA coding sequence: down regulation of expression by mRNA destabilization in the absence of translational repression. – Target: CdS
The potential of RNA molecules to exert regulatory functions in conjunction with auxiliary proteins has only recently been recognized and has emerged as a major field in molecular biology and biomedical research. In enterobacteria, such molecules constitute an ever-growing class of regulators of str
Global Geographies : Towards a regional system in the Middle East – SYSREMO
cf. rapport cf. rapport cf. rapport cf. rapport The research project SYSREMO (Global Geographies: Towards a regional system in the Middle East) is based on the hypothesis that economic and social transnational processes are reshaping the Middle East. These transnational networks and flows are increa
Spatial evolutionary ecology of host-parasite interactions. Genetic and epidemiological structuring. – SpatEvolEpid
Parasite evolution has important ecological and medical consequences. This research project considers the role of spatial epidemiological and genetic structuring for the evolution of host-parasite interactions. The proposal takes into account the spatial ecological dynamics of the populations of hos
Co-evolution and interactions within and between proteins – CoevolInterProt
How to represent and understand the couplings between amino acids within and between proteins? We previously analyzed this question in the context of individual proteins. We showed that a protein could comprise different groups of amino acids that co-evolve relatively independently, and are associat
Titre du projet en anglais New constraints on climate changes inferred from past variability of the CO budget – COCLICO
Many reactive species characterized by relatively short lifetimes (in the range of few weeks to few months) indirectly influence the climate system by affecting the cleansing power of the atmosphere and cycles of major atmospheric greenhouse gases. Notably, carbon monoxide (CO) plays a central role